Boltz
Boltz is a family of open-source biomolecular structure prediction models developed primarily at MIT's Computer Science and Artificial Intelligence Laboratory (CSAIL) and the MIT Jameel Clinic.
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Boltz-2
Boltz-2 is an open-source biomolecular foundation model that jointly predicts the 3D structure of biological complexes and the binding affinity between small molecules and proteins.
Evo 2 (genomic model)
Evo 2 is a genomic foundation model built by the Arc Institute together with NVIDIA, Stanford University, and collaborators, and first released in February 2025.
OpenFold
OpenFold is an open source, trainable, GPU friendly PyTorch reimplementation of AlphaFold 2, developed initially by the AlQuraishi lab at Columbia University and then governed by the OpenFold Consortium
OpenScience
OpenScience is an open-source, model-agnostic AI research workbench built by Synthetic Sciences, a San Francisco startup in Y Combinator's Winter 2026 batch.
Proto (Generative Biology)
Proto is an open-source programming framework for generative biology developed by researchers at Stanford University and the Arc Institute.